CoQ10 Backgrounder

Other names: Coenzyme Q10, Co Q10, Ubiquinone, vitamin q

CoQ10 is a compound of naturally occurring found in each cell in the body. Another name for the CoQ10, ubiquinone, comes from the word ubiquitous, which means "found everywhere."

CoQ10 plays a key role in the production of energy in the mitochondria, the part of a cell responsible for the production of energy in the form of ATP.

Congestive heart failure
Cardiomyopathy
Recovery and prevention of heart attack
High blood pressure
Diabetes
Gum disease
Renal failure
Migraine
Counter the effects of prescription drugs
Parkinson's disease
Weight lossheart failure
People with heart failure were found to have lower levels of CoQ10 in cardiac muscle cells. Double-blind research suggests that CoQ10 may reduce symptoms associated with heart failure, such as shortness of breath, difficulty sleeping, and swelling. CoQ10 is thought to increase the production of energy in the heart muscle, increase in the strength of the pumping action. Recent human studies, however, did not argue this.

In a study, 641 persons of heart failure were distributed randomly to receive either CoQ10 (2 mg / kg body weight) or a placebo over the standard treatment. The people who took CoQ10 had a significant reduction in the severity of symptoms and less hospitalization.

In another study, 32 patients with heart transplantation waiting for Terminal heart failure received 60 mg of CoQ10 or placebo for 3 months. Patients who took CoQ10 has experienced a significant improvement of the functional State, the clinical symptoms and quality of life, however it there was no change in echocardiography (cardiac ultrasound) or objective markers.

A randomized study 55 patients with congestive heart congestive to receive 200 mg per day of CoQ10, or placebo in addition to standard treatment. Although serum concentrations of CoQ10 has increased in patients receiving CoQ10 CoQ10 affect ejection fraction, the maximum consumption of oxygen, or exercise duration.

A long-term study examines the use of CoQ10 100 mg or placebo in addition to standard treatment 79 patients with stable chronic heart failure. The results indicate that CoQ10 that slightly improved exercise maximum capacity and the quality of life compared to placebo.

Cardiomyopathy

Several small trials have found that CoQ10 may be useful for certain types of cardiomyopathy.

Parkinson's disease

The decrease in the CoQ10 were also observed in people with Parkinson's disease. Preliminary research has found that increasing CoQ10 may increase levels of the neurotransmitter dopamine, which seems to be lowered in people with Parkinson's disease. It has also been suggested that CoQ10 may protect the brain cells from damage by free radicals.

A small randomized controlled trial examined the use of CoQ10 360 mg or placebo in 28 patients treated and stable Parkinson's. After 4 weeks, CoQ10 has provided a slight but significant light significantly improved symptoms of Parkinson's disease at the beginning and significantly improved the results of the Visual function.

A larger trial 16 months, funded by the National Institutes of Health has explored the use of CoQ10 (300, 600, or 200 mg/day) or placebo in 80 patients with early stage of Parkinson's disease. The results suggest that CoQ10, especially in the 1 200 mg / day dose, had a significant reduction in disability than those who took a placebo.

CoQ10 and statin drugs

Some research suggests that statin drugs or inhibitors of HMG - CoA reductase, a class of drugs used to lower cholesterol, may interfere with the production of the body of CoQ10. However, research on the use of CoQ10 supplements in people taking statins is still not conclusive, and it is not routinely recommended in combination with statin therapy.

Diabetes
In a randomized controlled trial of 12 weeks, 74 people with diabetes type 2 were distributed randomly assigned to receive either 100 mg CoQ10 twice daily, 200 mg per day of Fenofibrate (a lipid regulating drug), both, or neither for 12 weeks. CoQ10 supplementation significantly improved blood pressure and blood glucose control. However, two studies have found that CoQ10 supplementation failed to find an effect any blood glucose control. Gum disease
A small study examined the topical application of CoQ10 in the periodontal pocket. Ten male patients with periodontal pockets 30 periodontitis were selected. During the first 3 weeks, patients applied topical CoQ10. There was a significant improvement of symptoms.

A typical dose of CoQ10 is 30 to 90 mg per day, taken in divided doses, but the recommended amount can be as high as 200 mg per day.

CoQ10 is fat-soluble, so it is better absorbed than with a meal that contains oil or grease.

The clinical effect is not immediate and may take up to eight weeks.

Consult your doctor before trying to CoQ10, especially if you have heart disease, renal failure or cancer.

CoQ10 side effects include diarrhea and rash.

CoQ10 is used in combination with standard therapy, not to replace.

CoQ10 may lower blood sugar, for people with diabetes should not use CoQ10 unless under the supervision of a physician. CoQ10 may lower blood pressure.

The safety of q10 Co in pregnant women or lactating or children has not been established.

Learn more about CoQ10 potential drug interactions.

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