Regular physical activity reduces the many risks to health including dementia and certain cancers, study finds

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ScienceDaily (16 novembre 2010) — Exercice régulière peut réduire les conditions de santé physique et mentale autour de deux douzaines et ralentir comment rapidement les âges de corps, selon un examen de recherche résumant les principales constatations de 40 articles publiés entre 2006 et 2010.

L'article fournit une source inestimable pour les éditeurs de nouvelles et de fonctionnalité, comme il est divisé en plusieurs sections clés, allant de : "Pourquoi devrais j'exercer » « Je suis trop occupé, je n'ai pas de temps. »Les conditions de santé couvertes par l'examen comprennent : cancer, maladies cardiaques, démence, accidents vasculaires cérébraux, diabète de type 2, dépression, l'obésité et hypertension artérielle.

Les personnes qui prennent l'exercice régulier pourraient réduire leur risque de développer des conditions de santé physique et mentale autour de deux douzaines--y compris certains cancers et la démence--et ralentir la rapidité avec laquelle leur corps se détériore en vieillissant.

Un examen des recherches approfondies, publié dans le numéro de décembre du IJCP, l'International Journal of Clinical Practice, affirme que, hormis de ne pas fumer, l'activité physique est le choix de mode de vie plus puissant que toute personne peut faire pour améliorer leur santé.

Physiothérapeute et conférencier Leslie Alford, de l'Université d'East Anglia a examiné 40 articles couvrant les dernières recherches internationales publiées entre 2006 et 2010.

« La littérature examinée montre que combien vivent et saine comment ils sont dépend d'un mélange complexe de facteurs, y compris leur mode de vie, où ils vivent et même chance », explique M. Alford. "Individus ont un élément de contrôle sur certains de ces facteurs, y compris l'obésité, alimentation, activité physique et effets de la cigarette.

« Bien que le sujet de mon étude sur la santé des hommes, les messages sur l'activité physique sont pertinentes pour les deux sexes et tous les groupes d'âge. »

Avantages pour la santé identifiés par l'examen sont les suivants :

Modérée régulière d'une activité physique intense est associée à un risque moindre de maladies coronariennes et ischémique et stroke.A hémorragique croissant de preuves suggère qu'accroître l'activité physique peut aussi réduire le risque de certains types de cancers, l'ostéoporose, le diabète de type 2, dépression, obésité et pressure.Evidence de sang élevé des effets bénéfiques de la physique de l'activité dans la prévention primaire et de la gestion du cancer est en croissance et il existe un lien entre les niveaux plus élevés de l'activité physique et inférieur du cancer mort rates.Research a trouvé que pied ou à vélo au moins une demi-heure par jour est associé à une réduction dans le cancer et que lorsque cela est augmentée à une heure de l'incidence du cancer tombe par 16 par cent.Evidence est mélangée lorsqu'il s'agit de cancers spécifiques.Recherche a montré une forte relation entre augmentation de l'activité physique et réduit de cancer du côlon chez les deux sexes. Et les hommes qui sont plus actifs au travail--pas seulement assis à un bureau--ont des taux de cancer de la prostate cancer.Other études montrent que l'activité physique après que diagnostic peut faciliter la récupération et améliorer les outcomes.Studies n'ont également démontré que les hommes qui sont actifs physiquement sont moins susceptibles d'éprouver l'érection problems.There croît preuve que l'activité physique peut réduire le risque de démence chez les personnes âgées.

Les recommandations identifiées par l'examen comprennent :

Des adultes en bonne santé, entre 18 et 65 ans doivent s'efforcer de 150 minutes d'activité physique d'intensité modérée par semaine, tels que 30 minutes de marche rapide, cinq jours par semaine.Et les personnes qui s'engagent plus vigoureux exercice d'intensité, comme le jogging, doivent s'efforcer de 20 minutes, âgés de trois jours un adultes week.Healthy devraient viser à deux séances d'entraînement à la force une semaine que le travail avec les gens de groups.Older pour le muscle grand du corps peut bénéficier d'exercice qui aide à maintenir leur équilibre et flexibility.People qui sont physiquement actifs devrait continuer à exercer même quand ils deviennent le milieu ou les personnes âgées et celles qui ne sont pas devrait augmenter leur tabagisme activity.Not physique et suivant un régime alimentaire sain est aussi important.

« Dans l'idéal, pour obtenir le maximum de santé avantages personnes devraient exercer, pas fumer, manger sainement et ont un indice de masse corporelle de moins de 25 », explique M. Alford. Plus de ces caractères en bonne santé, une personne a, ils sont moins susceptibles de développer une gamme de troubles chroniques. Même si les gens ne peuvent pas renoncer à fumer et maintenir un poids santé, ils peuvent gagner encore bienfaits pour la santé d'une augmentation de la quantité d'activité physique régulière, qu'ils prennent.

« L'inactivité physique entraîne des changements physiopathologiques généralisées de notre corps.Il semble que notre corps ont évolué à fonction de façon optimale à un certain niveau d'activité physique que bon nombre d'entre nous simplement n'atteignent pas dans notre mode de vie moderne, sédentaires.

« Ce qui ressort de la recherche est que les hommes et les femmes de tous âges devraient être encouragées à être plus actifs dans l'intérêt de leur santé à long terme. »

Note du rédacteur : cet article n'est pas destiné à fournir des conseils médicaux, de diagnostic ou de traitement.

Source de l'histoire :

L'histoire ci-dessus est reproduit (avec des adaptations rédactionnelles par le personnel de ScienceDaily) de matériaux fournis par Wiley - Blackwell, via AlphaGalileo.

Référence de la revue :

L. Alford.Ce que les hommes doivent savoir sur l'impact de l'activité physique sur leur santé.International Journal of Clinical Practice, 2010 ;64 (13): 1731 DOI : 10.1111/j.1742-1241.2010.02478.x

Remarque : Si aucun auteur n'est donné, la source est citée au lieu de cela.

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Canola-type reduces the level of Fibrinogen rapeseed oil, a cause of thrombosis and inflammation, study finds

PharmaLive.com (8 November 2010) - research on fatty acids in the universities of Helsinki and Tampere, consumption of rapeseed oil canola-type reduces harmful health Fibrinogen level in the body. Caused by an imbalance in essential fats in your diet, increased, Fibrinogen level decreases when saturated fatty acids are replaced with rapeseed oil.

The results of the research was published in journal prostaglandins, Leukotrienes the and essential fatty acids.

A complex equilibrium, Hemostatic balance, prevails in the bloodstream.A player in this issue of balancing is Fibrinogen, blood coagulation factor important unique.Un Fibrinogen level promotes the creation of thrombosis and maintains the inflammation in the body. An increase in the level of Fibrinogen is closely linked with, for example, cardiovascular disease, stroke, diabetes, Alzheimer's disease and dementia.

New research shows for the first time that an increase of Fibrinogen from the blood level is largely caused by the lack of Omega-3-alpha-linolenic acid in the diet food .Lorsqu ' there is too little of this beneficial fatty acid in diet, an imbalance between the fatty acids in the body is créé.Lorsque Omega-3-alpha-linolenic acid level is too low, the body begins to produce the most harmful Omega-6-arachidonic acid Omega-6-linoleic acid, creating hormone-type compounds that cause thrombosis and inflammation. According to researchers, the composition of rapeseed oil grease is optimal at the Organization essential fatty acids and is therefore well suited to reduce levels of Fibrinogen in blood.

Fibrinogen and reduces cholesterol levels

All subjects of research 42, with many levels with high cholesterol, and Fibrinogen participated in the subjects recherche.Les replaced study a quarter of dietary fats, margarine, cheese, butter), they were used for rapeseed oil.Used oil was spring canola-quality oil turnip rape.They took on a spoon soup spoons of oil per day, for example, mixed with a salade.La doubled rapeseed oil dose the intake of Omega-3-alpha-linolenic acid during the period of the experiences of six semaines.En because of the regime, at all levels of Fibrinogen higher than the average has decreased by approximately 30%.

Research shows that Fibrinogen control and changing the fat consumed cholesterol is a starting point in the prevention of diseases as well as from the point of view of individual medical treatment réussi.Selon Laakso, PhD at the Faculty of pharmacy of the University of Helsinki, the harmful effects of fats, for example, older persons could be easily corrected by switching of rapeseed oil fat quarter.Laakso also recommends more cholesterol, health care facilities must measure the levels of Fibrinogen patients.

Editor's note: this article is not intended to provide medical advice, diagnosis or treatment.

Source of the story:

The story above is reproduced (with drafting adaptations by staff at PharmaLive.com) materials provided by University of Helsinki via AlphaGalileo.

Reference of the review:

T. Seppänen-Laakso, i. Laakso, t. Lehtimäki, r. Rontu, e. Moilanen, t. Solakivi, l. Seppo, h. Vanhanen, k. Kiviranta, r. Hiltunen.High plasma Fibrinogen caused by acid intake inadequate a-linolenic acid can be reduced by replacing fat with rapeseed canola-type oil.Prostaglandines, Leukotrienes and essential fatty acids, 2010; 83 (1): 45 DOI: 10.1016/j.plefa.2010.02.001

Note: If no author is given, the source is cited for this.

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Genes linking the timing of puberty fatty body among women

PharmaLive.com (22 November 2010) - scientists have discovered 30 new genes that control the age of sexual maturity among women. Notably, many of these genes Act on body weight regulation or biological pathways associated with the metabolism of lipids. The study, which appears in Nature Genetics, was a collaboration with the international consortium of ReproGen, which included scientists 175 104 institutions around the world, including the Boston University School of Medicine (BUSM) and Boston University School of Public Health effort.

Female puberty occurs normally aged 11 to 14 years.If a child reaches a particular weight (about 45 kg / 100 lbs), the onset of puberty is heavier déclenché.Le child, earlier puberty occurs, possibly affect risk of disease later.

Massimo Mangino, an author of Twin Department College of London's King's Department, explains: "it's fascinating influence common genetic variants in early puberty and weight gain."The findings give us clues on how closely linked are different biological processes. »

Appearance raw rules, the appearance of the first menstruation in girls, indicate the achievement of their reproductive capacity and are widely used the pubertal time marker. Age of onset of the first rules varies greatly and depends heavily on nutritional status. Appearance first rules are linked to many adverse health later in life, including cancer of the breast, cancer of the endometrium, obesity, diabetes type results 2 and cardiovascular disease, as well as shorter adult stature.

To identify the locus for age at the time of the appearance of the first rules, researchers conducted a meta-analysis of 32 scale genome association studies on women and overseeing of United States, Europe and Australia and has carried out close to 15,000 women supplémentaires.En more loci known LIN28B and 9q31.2, researchers identified 30 new loci of early menarche and found replication studies evocative for another 10 loci.According to the researchers, the new loci loci included four previously associated with body mass index, three in or near other genes involved in energy homeostasis and three in or near genes involved in hormonal regulation.Ingenuity and the entire gene enrichment pathway analysis identified the COA biosynthesis and fatty acids such as biological processes related to the appearance of the first rules.

"Our study found genes involved in regulating hormone, the development of cells and other biological pathways associated with the mechanisms of age at the onset of the first rules which shows that the timing of puberty is controlled by a range complex biological processes" said lead author Joanne Murabito, MD, MSC, Associate Professor of medicine at the BUSM and Director of the clinic and researcher at the Framingham Heart Study.

"Many of the genes of the rules have been associated with weight and obesity in other studies suggesting some women may have a genetic susceptibility to weight gain and the puberté.Il early is important to understand that these"genetic factors"may be modified by changes in the way of vie.Les efforts to reduce or prevent obesity should in turn help to reduce the appearance at the beginning of puberty in girls, child" added Murabito.

The next steps according to the researchers are to review the results among women of other race / ethnic groups, as well as to examine whether these genetic loci influence growth and to determine if the associations are actuated by adiposity corporelle.Ce future work measures will help to elucidate the biological mechanism underlying the associations.

Editor's note: this article is not intended to provide medical advice, diagnosis or treatment.

Source of the story:

The story above is reproduced (with drafting adaptations by staff at PharmaLive.com) materials provided by Boston University Medical Center, via EurekAlert!, a service of AAAS.

Reference of the review:

Cathy E Elks et al. thirty new loci for age at the time of the appearance of the first rules by a meta-analysis of genome-wide association studies identified .Nature Genetics, 21 November 2010 DOI: 10.1038/ng.714

Note: If no author is given, the source is cited for this.

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Overweight mainly a problem among the richest women in countries with low and middle income

PharmaLive.com (23 November 2010) - a new study from the Harvard School of Public Health (HSPH) finds that the body high mass (IMC) in developing countries remains primarily a problem of the rich. The results suggest that the development of overweight and obesity among the poor who already took place in rich countries is not yet arrived in developing countries.

The study appears in the advance of the American Journal of Clinical Nutrition Online Edition and will appear in the next printed edition.

"Previous research on the increase in overweight and the burden of obesity in developing countries have assumed that the burden is shared by everyone in these countries;" "However, we found that social reasons weight continue to closely resemble the unequal distribution of income and other resources," said S V Subramanian, lead author of the paper and an associate professor in the Department of the company, human development and health to the HSPH.

Subramanian and colleagues analyzed data from representative samples nationally 538,140 women aged 15 to 49 learned surveys on the health of the population and carried out in 54 low and middle-income countries between 1994 and 2008. They examined BMI, education, household wealth, and the gross domestic product per capita (pcGDP) of the country of origin of the women.The researchers found an association between BMI and richness in all countries except Moldova and of worldwide, an increase of 25% on wealth index measuring Kazakhstan.À has been associated with an increase of 54% of BMI and an increase of 33% overweight. Similar patterns were observed in urban and rural areas in the country. There is no strong association between weight and education or pcGDP.

Researchers theorize that these results could be due to a number of factors, including women in higher income groups are more likely to have diets rich in animal fat and low-income women. Also, cultural standards in developing countries can promote forms of fat women's richest. Richest women are also less likely to engage in regular physical working poor women.

IMC prevalence and growing overweight are important in many countries public health concerns, their allocation between socioeconomic groups must make a central consideration in the development of policies to improve the nutritional status of populations in the developing countries, according to researchers.

"Our findings have serious implications," said Subramanian. "If obesity is mainly concentrated in the rich, valuable public resources should be targeted to reduce overweight or should be devoted to policies aimed at improving the nutritional outcomes among the poor?"He added:"the fact that the burden of the overweight and underweight is concentrated largely in two distinct socio-economic groups actually a good thing from the point of view policy, the challenge is how to find a balance between the emphasis in terms of priorities".

No direct funding source supported this study.Macro International Inc. has provided access to the population and health surveys.Subramanian is supported by a grant from the U.S. National Heart, Lung and Blood Institute career development.

Editor's note: this article is not intended to provide medical advice, diagnosis or treatment.

Source of the story:

The story above is reproduced (with drafting adaptations by staff at PharmaLive.com) materials provided by Harvard School of Public Health, via EurekAlert!, a service of AAAS.

Reference of the review:

S. Subramanian, j. M. Perkins, e. Ozaltin, g. Davey Smith.Weight of nations: a socio-economic analysis of women in countries with low and middle income.American Journal of Clinical Nutrition, 2010; DOI: 10.3945/ajcn.110.004820

Note: If no author is given, the source is cited for this.

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Experts issue recommendations for the treatment of post-bariatric surgery patients

PharmaLive.com (4 November 2010) - the Endocrine Society has published a new line of clinical practice, endocrine and nutrition for adults after surgery Bariatric, Managing Director, including those with diabetes mellitus. The directive contains a series of clinical recommendations developed by a group of expert evidence-based. The guideline is published in the issue of the journal of clinical endocrinology and metabolism (JCEM), a publication of the endocrine disruptive company November 2010.

The United States obesity rate increased by 24% between 1999 and 2004. Bariatric Surgery has gained wide acceptance in the treatment of obesity serious, especially when complicated by type 2 diabetes.Common operations include laparoscopic banding procedures and gastric surgery, which limit the amount of food in the stomach and intestine .the patients undergoing Bariatric Surgery may continue to live in the resurgence of weight and may also be associated Comorbidities, including type 2 diabetes, the disease Polycystic disease ovarian, metabolic disease of bone, foie gras, hypertension and obstructive sleep apnea.

«Weight loss surgery is not a guarantee of success, and patients need post-operative care, said David Heber, MD, Dr., University of California and Chairman of the task force developed guidelines.»To help prevent weight regain, co-morbidity is managed appropriately and facilitate the transition to life after surgery Bariatric, the guidance recommends that patients receive the support of a multidisciplinary team comprising a doctor experienced front-line, an endocrinologist or a gastroenterologist.»

Other recommendations of the guideline include:

Active nutrition education of the patient and clinical support to prevent and detect the nutritional deficiencies for patients undergoing bariatric surgery.management of potential nutritional deficiencies for patients undergoing procedures as well as strategies malabsorption compensate for food intolerance in patients who have had a malabsorption procedure to reduce the risk of clinically significant nutritional deficiencies;patient enrollment in a comprehensive program for power management and lifestyle;andFuture research to address the effectiveness of endocrine post-operative intensive and nutritional care in reducing morbidity and mortality of chronic diseases associated with obesity.

Hormone, affiliate society patient education Foundation disruptors, has published a guide for patients described compagnon.Il steps patients and their health care team should take to avoid nutritional deficiencies and complications as a result, such as protein malnutrition loss or bone, particularly after malabsorption.Le guide operations explains that, in most patients, health problems related to obesity disappear or improve substantially after chirurgicale.Il encourages patients also have expectations realistic about what surgery can do for them and changes in lifestyle that they lose weight and keep it off the coast.

Guide for patients are located online at: www.hormone.org/bariatric-patient-guide.

Editor's note: this article is not intended to provide medical advice, diagnosis or treatment.

Source of the story:

The story above is reproduced (with drafting adaptations by staff at PharmaLive.com) material supplied by the endocrine disruptive company, via EurekAlert!, a service of AAAS.

Note: If no author is given, the source is cited for this.

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HYPERACTIVE AFP gene causes eating and obesity

PharmaLive.com (16 November 2010) - scientists have gained strong confirmation of the direct connection between the AFP gene and obesity, obtaining the first direct evidence that the hyperactivity of the gene leads to eat and obesity in mice.

University of Oxford and the Council of medical research (MRC), the Wellcome Trust and the MRC funded research team have published their results in the journal Nature Genetics.

Results team of suggested that the gene may be a promising target for the development of anti-obesity drugs that Act by turning to the activity of the gene.

"This work we confident that the AFP is an important gene that contributes to obesity," said Frances Ashcroft the Professor of the Oxford University Department of Physiology, Anatomy and genetics, and one of the leaders of research. "Too much activity of this gene can lead to put on weight by overeating.

"We now think the development of drugs that turn down the activity of AFP gene in the form of pills potential anti-obesity b.c ' is a long way off the coast and there is no guarantee of success, but it is an attractive prospect,' she adds."

In 2007, an international team of researchers, including Oxford, scientists announced that they had identified the first genetic variant that may be linked to an increased risk of obesity in a large genome-wide study.

The only change in the DNA sequence of lay of AFP gene.Persons with two copies of this variant genetic (approximately 16% of the population of European origin were two copies) have been the heaviest 3 kg on average than those without.

While it is an important result, genome-wide association studies are often first step allowing then detail to identify the mechanisms behind the observed connection in this case to obesity research.

In particular, surveys genome-scale cannot be certain identified genetic variation directly increases the risk of obesity .the change in DNA could be an indicator or a marker important gene is located nearby, or DNA modification could lie in a control element that regulates a different gene distance.

Researchers of the study, led by Mr. Roger Cox MRC Harwell and Professor Frances Ashcroft, Oxford University, set out determine if there were differences in the activity of the gene of OTF itself directly causing the increase in body weight.

Scientists mimic mice with extra copies of the AFP gene.These mice were in good health, but eat more and becoming fatter than normal mice.

Female with two additional copies of the gene AFP, when subjected to a standard diet, mice has become 22% heavier than normal female mice after 20 weeks.The difference in weight for male mice was 10 lined researchers have also show that the difference came because the mice with AFP hyperactivity consume more food.(There is no suggestion that differences in humans with variants of the AFP weight are or could be almost as large or necessarily affect gender in a similar proportion.)

Chris Church, MRC Harwell and author of the study PhD student, said: "for the first time, we have provided convincing evidence that the FTO gene causes obesity .the ' next step is to understand how it performs, for example if it increases the appetite by influencing our brains or modifies messages from our reserves of fat and other times we know how AFP causes obesity tissus.Une, we have the opportunity to seek to develop drugs for treatment."

Genome-wide association studies did a fantastic job narrowing zones in the genome of the head of obesity.They have provided guides from the place to go, but these areas remain pinning a specific gene as we've done here for the first time with the AFP.Mouse model has allowed us to achieve this goal in only a few years, and we hope the same process will now apply to other areas of genes involved in obesity, allowing scientists to confirm precisely that other genes may predispose us to become overweight.»

From 1 to 3 persons in the United Kingdom are obese or .the ' obesity predisposes people to many diseases, including heart disease, type 2 diabetes and the estimated amount cancer.Le of obesity in the NHS is approximately 1 billion pounds per year, with an additional £ 2.3 to 2.6 billion pounds per year to the economy as a whole.

"This gene is the novel research on obesity and it will be interesting to know how it works," explains Mr Roger Cox, unity of genetics in mammals of the Council of medical research at Harwell and one of the leaders of research. "We now have to address these issues mouse models.»

Editor's note: this article is not intended to provide medical advice, diagnosis or treatment.

Source of the story:

The story above is reproduced (with drafting adaptations by staff at PharmaLive.com) materials provided by The University of Oxford.

Reference of the review:

Chris Church, Lee Moir, Fiona McMurray, Christophe Girard, Gareth T Banks, Lydia Teboul, Sara Wells, Jens C Brüning, Patrick Nolan, Frances M Ashcroft, Roger D. Cox.Tre overexpression leads to an increased food intake and gives rise to obesity .Nature Genetics, 2010; DOI: 10.1038/ng.713

Note: If no author is given, the source is cited for this.

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